The Breakthrough Challenge
We raise funds to support breakthroughs in cancer research at Penn Medicine's Abramson Cancer Center (ACC). Founded in 2013, the Breakthrough Challenge unites patients, researchers, their families, and friends for a scenic and inspiring bike ride through Eastern PA's beautiful Oley Valley. To date, the Breakthrough Challenge has donated $2,825,000 to the ACC, funding 63 research projects. 100% of all participant-raised dollars are donated directly to cancer research.

Our 2025 Fundraising Goal
$221,574
Raised of $300,000
Meet the Match Challenge

Meet the Match Challenge Round Two has been met!
Round 2 of the Meet the Match Challenge has concluded as of 4:55PM, Friday, August 22nd, 2025, with all matching funds being used.
If you received a donation between August18th and August 22nd, before 4:55PM, we will be posting a matching donation from our Match Challenge Partner, the Zent Family Foundation.
You should expect to see your matching donation before Monday, August 25th, 2025.
Thank you for your commitment to our Breakthrough Challenge cause!
MATCH CHALLENGE PARTNER: The Zent Family Foundation
Breakthroughs in Action

Thank You To Our Fundraisers!
Top Individuals
View AllBruce Levine
$27,640.00 raised of $30,000.00
Lynn Schuchter
$25,935.76 raised
Bo Ebby
$13,400.00 raised of $15,000.00
William Wilson
$12,090.00 raised of $1,000.00
Lou Starzl
$12,075.00 raised of $12,500.00
Top Teams
View AllMission Melanoma
$51,470.76 raised of $10,000.00
Keystone State Ride
$46,373.53 raised of $30,000.00
CARs Pedaling For Cures
$29,265.00 raised of $30,000.00
Team BC
$19,717.53 raised of $20,000.00
Team Krieger
$11,100.00 raised of $10,000.00
Donate To an Indvidual or a Team
Donate NowJoin Us to Make a Difference!
